Essential tremor is not a neurodegenerative disease

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Essential Tremor: A Neurodegenerative Disease?

BACKGROUND Essential tremor (ET) is one of the most common neurological disorders among adults, and is the most common of the many tremor disorders. It has classically been viewed as a benign monosymptomatic condition, yet over the past decade, a growing body of evidence indicates that ET is a progressive condition that is clinically heterogeneous, as it may be associated with a spectrum of cli...

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What is essential tremor?

Classic essential tremor is a clinical syndrome of action tremor in the upper limbs (at least 95 % of patients) and less commonly the head, face/jaw, voice, tongue, trunk, and lower limbs, in the absence of other neurologic signs. However, the longstanding notion that essential tremor is a monosymptomatic tremor disorder is being challenged by a growing literature describing associated disturba...

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How Common Is Essential Tremor?

lent than Parkinson’s disease in Arabic villagers in Israel (ET prevalence = 0.78% vs. PD prevalence = 1.44%) [12] ; however, those results are atypical. The incidence of ET has been examined in only 2 studies [13, 14] . The incidence rate reported for ET, based on a populationbased study (the NEDICES study) [13] , was substantially higher (6.3 per 1,000 person-years) than that reported in the ...

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How common is essential tremor?

lent than Parkinson’s disease in Arabic villagers in Israel (ET prevalence = 0.78% vs. PD prevalence = 1.44%) [12] ; however, those results are atypical. The incidence of ET has been examined in only 2 studies [13, 14] . The incidence rate reported for ET, based on a populationbased study (the NEDICES study) [13] , was substantially higher (6.3 per 1,000 person-years) than that reported in the ...

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Thalamic physiology of intentional essential tremor is more like cerebellar tremor than postural essential tremor

The neuronal physiological correlates of clinical heterogeneity in human essential tremor are unknown. We now test the hypothesis that thalamic neuronal and EMG activities during intention essential tremor are similar to those of the intention tremor which is characteristic of cerebellar lesions. Thalamic neuronal firing was studied in a cerebellar relay nucleus (ventral intermediate, Vim) and ...

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ژورنال

عنوان ژورنال: Neurodegenerative Disease Management

سال: 2012

ISSN: 1758-2024,1758-2032

DOI: 10.2217/nmt.12.23